Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes

Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes

Detection of somatic mutations in HLA genes using whole-exome sequencing (WES) is hampered by the high polymorphism of the HLA loci, which prevents alignment of sequencing reads to the human reference genome. We describe a computational pipeline that enables accurate inference of germline alleles of...

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Bibliographic Details
Main Authors: Shukla, Sachet A., Rooney, Michael S., Rajasagi, Mohini, Tiao, Grace, Dixon, Philip M., Lawrence, Michael S., Stevens, Jonathan, Lane, William J., Dellagatta, Jamie L., Steelman, Scott, Sougnez, Carrie, Cibulskis, Kristian, Kiezun, Adam, Brusic, Vladimir, Wu, Catherine J., Getz, Gad
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747795/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747795/

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