Absolute quantification of somatic DNA alterations in human cancer

Absolute quantification of somatic DNA alterations in human cancer

We developed a computational method (ABSOLUTE) that infers tumor purity and malignant cell ploidy directly from analysis of somatic DNA alterations. ABSOLUTE can detect subclonal heterogeneity, somatic homozygosity, and calculate statistical sensitivity to detect specific aberrations. We used ABSOLU...

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Bibliographic Details
Main Authors: Carter, Scott L., Cibulskis, Kristian, Helman, Elena, McKenna, Aaron, Shen, Hui, Zack, Travis, Laird, Peter W., Onofrio, Robert C., Winckler, Wendy, Weir, Barbara A., Beroukhim, Rameen, Pellman, David, Levine, Douglas A., Lander, Eric S., Meyerson, Matthew, Getz, Gad
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383288/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383288/

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