NLRP6 Negatively Regulates Innate Immunity and Host Defense Against Bacterial Pathogens

Members of the intracellular nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family contribute to immune responses through activation of NF-κB, type I interferon and inflammasome signaling1. Mice lacking the NLR family member NLRP6 were recently shown to be susceptible to col...

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Bibliographic Details
Main Authors: Anand, Paras K., Malireddi, R. K. Subbarao, Lukens, John R., Vogel, Peter, Bertin, John, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422416/