Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria

Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria

Farnesylated prelamin A is a processing intermediate produced in the lamin A maturation pathway. Accumulation of a truncated farnesylated prelamin A form, called progerin, is a hallmark of the severe premature ageing syndrome, Hutchinson-Gilford progeria. Progerin elicits toxic effects in cells, lea...

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Bibliographic Details
Main Authors:	Cenni, V., Capanni, C., Columbaro, M., Ortolani, M., D'Apice, M.R., Novelli, G., Fini, M., Marmiroli, S., Scarano, E., Maraldi, N.M., Squarzoni, S., Prencipe, S., Lattanzi, G.
Format:	Online
Language:	English
Published:	PAGEPress Publications 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284238/

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