Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H2O2

Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H2O2

A proteomic-based search for novel substrates of Akt was undertaken in C2C12 murine muscle cells. Our data demonstrate that Akt isoform 2 phosphorylates Ankrd2 at Serine 99 in response to H2O2 stimuli, regulating muscle differentiation rate.

Bibliographic Details
Main Authors: Cenni, Vittoria, Bavelloni, Alberto, Beretti, Francesca, Tagliavini, Francesca, Manzoli, Lucia, Lattanzi, Giovanna, Maraldi, Nadir M., Cocco, Lucio, Marmiroli, Sandra
Format: Online
Language:English
Published: The American Society for Cell Biology 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154889/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154889/

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