Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates

Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates

The cell nucleus is structurally and functionally organized by lamins, intermediate filament proteins that form the nuclear lamina. Point mutations in genes that encode a specific subset of lamins, the A-type lamins, cause a spectrum of diseases termed laminopathies. Recent evidence points to a role...

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Bibliographic Details
Main Authors: Sieprath, Tom, Corne, Tobias DJ, Nooteboom, Marco, Grootaert, Charlotte, Rajkovic, Andreja, Buysschaert, Benjamin, Robijns, Joke, Broers, Jos LV, Ramaekers, Frans CS, Koopman, Werner JH, Willems, Peter HGM, De Vos, Winnok H
Format: Online
Language:English
Published: Taylor & Francis 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615646/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615646/

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