Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria

Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria

Farnesylated prelamin A is a processing intermediate produced in the lamin A maturation pathway. Accumulation of a truncated farnesylated prelamin A form, called progerin, is a hallmark of the severe premature ageing syndrome, Hutchinson-Gilford progeria. Progerin elicits toxic effects in cells, lea...

Full description

Bibliographic Details
Main Authors: Cenni, V., Capanni, C., Columbaro, M., Ortolani, M., D'Apice, M.R., Novelli, G., Fini, M., Marmiroli, S., Scarano, E., Maraldi, N.M., Squarzoni, S., Prencipe, S., Lattanzi, G.
Format: Online
Language:English
Published: PAGEPress Publications 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284238/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284238/

Similar Items