Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins

Transforming growth factor beta (TGFbeta) plays an essential role in bone homeostasis and deregulation of TGFbeta occurs in bone pathologies. Patients affected by Mandibuloacral Dysplasia (MADA), a progeroid disease linked to LMNA mutations, suffer from an osteolytic process. Our previous work showe...

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Bibliographic Details
Main Authors: Evangelisti, Camilla, Bernasconi, Pia, Cavalcante, Paola, Cappelletti, Cristina, D'Apice, Maria Rosaria, Sbraccia, Paolo, Novelli, Giuseppe, Prencipe, Sabino, Lemma, Silvia, Baldini, Nicola, Avnet, Sofia, Squarzoni, Stefano, Martelli, Alberto M., Lattanzi, Giovanna
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480690/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480690/

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