Proliferation-Attenuating and Apoptosis-Inducing Effects of Tryptanthrin on Human Chronic Myeloid Leukemia K562 Cell Line in Vitro

Proliferation-Attenuating and Apoptosis-Inducing Effects of Tryptanthrin on Human Chronic Myeloid Leukemia K562 Cell Line in Vitro

Tryptanthrin, a kind of indole quinazoline alkaloid, has been shown to exhibit anti-microbial, anti-inflammation and anti-tumor effects both in vivo and in vitro. However, its biological activity on human chronic myeloid leukemia cell line K562 is not fully understood. In the present study, we inves...

Full description

Bibliographic Details
Main Authors:	Miao, Shan, Shi, Xiaopeng, Zhang, Hai, Wang, Siwang, Sun, Jiyuan, Hua, Wei, Miao, Qing, Zhao, Yong, Zhang, Caiqin
Format:	Online
Language:	English
Published:	Molecular Diversity Preservation International (MDPI) 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131594/

Similar Items

CDA gene silencing regulated the proliferation and apoptosis of chronic myeloid leukemia K562 cells
by: Xiao-Fang Wei, et al.
Published: (2018-07-01)

Antiproliferative Effect of Aaptamine on Human Chronic Myeloid Leukemia K562 Cells
by: Jin, Meihua, et al.
Published: (2011)

Induction of human chronic myeloid leukemia K562 cell apoptosis by virosecurinine and its molecular mechanism
by: ZHANG, GANG, et al.
Published: (2014)

Anticancer activity of Pupalia lappacea on chronic myeloid leukemia K562 cells
by: Ravi, Alvala, et al.
Published: (2012)

Polyamine analog TBP inhibits proliferation of human K562 chronic myelogenous leukemia cells by induced apoptosis
by: WANG, QING, et al.
Published: (2015)

Induction of apoptosis by Cordyceps militaris fraction in human chronic myeloid leukemia K562 cells involved with mitochondrial dysfunction
by: Tian, Tian, et al.
Published: (2014)

MiR-370 sensitizes chronic myeloid leukemia K562 cells to homoharringtonine by targeting Forkhead box M1
by: Zhou, MinRan, et al.
Published: (2013)

Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives
by: Onambele, Liliane Abodo, et al.
Published: (2015)

Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicity
by: Wang, Zeng, et al.
Published: (2012)

Anticancer Effect and Apoptosis Induction of Gambogic Acid in Human Leukemia Cell Line K562 In Vitro
by: Chen, Jinhao, et al.
Published: (2015)

Hypericin-mediated photodynamic therapy induces apoptosis in K562 human leukemia cells through JNK pathway modulation
by: XU, YIXIAO, et al.
Published: (2015)

Growth inhibitory effects of crude pomegranate peel extract on chronic myeloid leukemia, K562 cells
by: Asmaa, Mat Jusoh Siti, et al.
Published: (2015)

Transferred BCR/ABL DNA from K562 Extracellular Vesicles Causes Chronic Myeloid Leukemia in Immunodeficient Mice
by: Cai, Jin, et al.
Published: (2014)

Apoptosis gene network regulated by delta-tocotrienol in K562 chronic myeloid leukaemia cells
by: Husna Zayadi
Published: (2017)

Apoptotic Mechanism of Human Leukemia K562/A02 Cells Induced by Magnetic Ferroferric Oxide Nanoparticles Loaded with Wogonin
by: Peng, Miao-Xin, et al.
Published: (2016)

The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells.
by: Anup S Pathania, et al.

The Synthetic Tryptanthrin Analogue Suppresses STAT3 Signaling and Induces Caspase Dependent Apoptosis via ERK Up Regulation in Human Leukemia HL-60 Cells
by: Pathania, Anup S., et al.
Published: (2014)

Naringenin suppresses K562 human leukemia cell proliferation and ameliorates Adriamycin-induced oxidative damage in polymorphonuclear leukocytes
by: LI, RUI-FANG, et al.
Published: (2015)

Lapatinib Induces Autophagy, Apoptosis and Megakaryocytic Differentiation in Chronic Myelogenous Leukemia K562 Cells
by: Huang, Huey-Lan, et al.
Published: (2011)

Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence
by: Drullion, C, et al.
Published: (2012)

Carbenoxolone induces apoptosis and inhibits survivin and survivin-ΔEx3 genes expression in human leukemia K562 cells
by: Moosavi, M.A, et al.
Published: (2011)

Autophagy Inhibition Enhances Daunorubicin-Induced Apoptosis in K562 Cells
by: Han, Weidong, et al.
Published: (2011)

Aclacinomycin A Sensitizes K562 Chronic Myeloid Leukemia Cells to Imatinib through p38MAPK-Mediated Erythroid Differentiation
by: Lee, Yueh-Lun, et al.
Published: (2013)

Alternative splicing of apoptosis-related genes in imatinib-treated K562 cells identified by exon array analysis
by: LIU, JING, et al.
Published: (2011)

CD44 targets Wnt/β-catenin pathway to mediate the proliferation of K562 cells
by: Chang, Guoqiang, et al.
Published: (2013)

In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells
by: Zhou, Qianxiang, et al.
Published: (2016)

(Nitrato-κ2 O,O′)bis(tryptanthrin-κN)silver(I)
by: Wu, Jie, et al.
Published: (2012)

Autophagy maintains ubiquitination-proteasomal degradation of Sirt3 to limit oxidative stress in K562 leukemia cells
by: Fang, Yixuan, et al.
Published: (2016)

Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells
by: Jung, Ji Hoon, et al.
Published: (2013)

Caveolin-1 contributes to realgar nanoparticle therapy in human chronic myelogenous leukemia K562 cells
by: Shi, Dan, et al.
Published: (2016)

Effects of THAP11 on Erythroid Differentiation and Megakaryocytic Differentiation of K562 Cells
by: Kong, Xiang-Zhen, et al.
Published: (2014)

Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA
by: Zhong, Yi-ning, et al.
Published: (2016)

The cytotoxicity effect of ant-444 in human chronic myeloid leukaemia cells (K 562)
by: Khalid, Nor Bahijah, et al.
Published: (2013)

Effect of ATRA on the expression of HOXA5 gene in K562 cells and its relationship with cell cycle and apoptosis
by: LIU, WEN-JUN, et al.
Published: (2016)

MiR-29 Induces K562 Cell Apoptosis by Down-Regulating FoxM1
by: Wang, Xiaofang, et al.
Published: (2015)

Olive (Olea europaea) Leaf Extract Induces Apoptosis and Monocyte/Macrophage Differentiation in Human Chronic Myelogenous Leukemia K562 Cells: Insight into the Underlying Mechanism
by: Samet, Imen, et al.
Published: (2014)

Growth inhibition and apoptosis induction of Scutellaria luteo-coerulea Bornm. & Sint. on leukemia cancer cell lines K562 and HL-60
by: Motaez, Mahsa, et al.
Published: (2015)

Resveratrol inhibits the phosphatidylinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in the human chronic myeloid leukemia K562 cell line
by: SUI, TAO, et al.
Published: (2014)

Effect of interaction of magnetic nanoparticles of Fe3O4 and artesunate on apoptosis of K562 cells
by: Wang, Ying, et al.
Published: (2011)

Potential of Bacillus subtilis lipopeptides in anti-cancer I: induction of apoptosis and paraptosis and inhibition of autophagy in K562 cells
by: Haobin Zhao, et al.
Published: (2018-05-01)