Antiproliferative Effect of Aaptamine on Human Chronic Myeloid Leukemia K562 Cells
We previously isolated aaptamine, a benzonaphthyridine alkaloid, from marine sponge Aaptos suberitoids. In this study, we investigated the anti-proliferative effect of aaptamine on chronic myeloid leukemia (CML) K562 cells. Aaptamine inhibited growth of K562 with a GI50 as 10 μM, and arrested cell c...
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Molecular Diversity Preservation International (MDPI)
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233409/ |