Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives

•We report the synthesis of tryptanthrin derivatives.•We report the activity of tryptanthrin derivatives against Plasmodium falciparum.•We discuss the potential of tryptanthrin derivatives as multi-stage drugs.•We recommend the formulation and testing of tryptanthrins in in vivo studies.

Bibliographic Details
Main Authors: Onambele, Liliane Abodo, Riepl, Herbert, Fischer, Rainer, Pradel, Gabriele, Prokop, Aram, Aminake, Makoah Nigel
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417838/