pERK-dependent defective TCR-mediated activation of CD4+ T cells in end-stage renal disease patients

pERK-dependent defective TCR-mediated activation of CD4+ T cells in end-stage renal disease patients

Abstract Background Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK) and p38, regulate diverse cellular programs by transferring extrace...

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Bibliographic Details
Main Authors: Ling Huang, Nicolle H. R. Litjens, Nynke M. Kannegieter, Mariska Klepper, Carla C. Baan, Michiel G. H. Betjes
Format: Article
Language:English
Published: BioMed Central 2017-06-01
Series:Immunity & Ageing
Subjects:
ESRD
T cells
ERK
p38
DUSP 6
MAPK
Online Access:http://link.springer.com/article/10.1186/s12979-017-0096-1

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