Pigment Epithelium-Derived Factor and its Phosphomimetic Mutant Induce JNK-Dependent Apoptosis and P38-Mediated Migration Arrest

Pigment Epithelium-Derived Factor and its Phosphomimetic Mutant Induce JNK-Dependent Apoptosis and P38-Mediated Migration Arrest

Background/Aims: Pigment epithelium-derived factor (PEDF) is a potent endogenous inhibitor of angiogenesis, and a promising anticancer agent. We have previously shown that PEDF can be phosphorylated, and that distinct phosphorylations differentially regulate its physiological functions. We also demo...

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Bibliographic Details
Main Authors: Alexander Konson, Sunila Pradeep, Cosimo Walter D’Acunto, Rony Seger
Format: Article
Language:English
Published: Karger Publishers 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
PEDF
phosphomimetic mutations
angiogenesis inhibitor
MAPK
JNK
p38
Online Access:https://www.karger.com/Article/FullText/492990

Internet

https://www.karger.com/Article/FullText/492990

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