Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor

Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor

Abstract Background Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders such as hemangiomas. The PTPs are also known to be notoriously difficul...

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Bibliographic Details
Main Authors: Robert D. Bongard, Michael Lepley, Khushabu Thakur, Marat R. Talipov, Jaladhi Nayak, Rachel A. Jones Lipinski, Chris Bohl, Noreena Sweeney, Ramani Ramchandran, Rajendra Rathore, Daniel S. Sem
Format: Article
Language:English
Published: BioMed Central 2017-05-01
Series:BMC Biochemistry
Subjects:
DUSP5
pERK
PTP1B
Azo
Dyes
Enzyme kinetics
Online Access:http://link.springer.com/article/10.1186/s12858-017-0083-3

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http://link.springer.com/article/10.1186/s12858-017-0083-3

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