Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

by Winnik, Stephan, Auwerx, Johan, Sinclair, David A., Matter, Christian M.
Published 2015

MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae

by Medvedik, Oliver, Lamming, Dudley W, Kim, Keyman D, Sinclair, David A
Published 2007

The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction

by Rascón, Brenda, Hubbard, Basil P., Sinclair, David A., Amdam, Gro V.
Published 2012

Head to Head Comparison of Short-Term Treatment with the NAD+ Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice

by Uddin, Golam M., Youngson, Neil A., Sinclair, David A., Morris, Margaret J.
Published 2016

Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability

by Kim, Jeongkyu, Sturgill, David, Tran, Andy D., Sinclair, David A., Oberdoerffer, Philipp
Published 2016

Correction: Nicotinamide Impairs Entry into and Exit from Meiosis I in Mouse Oocytes

by Riepsamen, Angelique, Wu, Lindsay, Lau, Laurin, Listijono, Dave, Ledger, William, Sinclair, David A, Homer, Hayden
Published 2015

Dietary restriction involves NAD+-dependent mechanisms and a shift toward oxidative metabolism

by Moroz, Natalie, Carmona, Juan J, Anderson, Edward, Hart, Anne C, Sinclair, David A, Blackwell, T Keith
Published 2014

Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase

by Vendrell, Alexandre, Martínez-Pastor, Mar, González-Novo, Alberto, Pascual-Ahuir, Amparo, Sinclair, David A, Proft, Markus, Posas, Francesc
Published 2011

O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway

by Ferrer, Christina M., Lu, Tong Y., Bacigalupa, Zachary A., Katsetos, Christos D., Sinclair, David A., Reginato, Mauricio J.
Published 2016

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

by Escande, Carlos, Nin, Veronica, Price, Nathan L., Capellini, Verena, Gomes, Ana P., Barbosa, Maria Thereza, O’Neil, Luke, White, Thomas A., Sinclair, David A., Chini, Eduardo N.
Published 2013

Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

by Rimmelé, Pauline, Bigarella, Carolina L., Liang, Raymond, Izac, Brigitte, Dieguez-Gonzalez, Rebeca, Barbet, Gaetan, Donovan, Michael, Brugnara, Carlo, Blander, Julie M., Sinclair, David A., Ghaffari, Saghi
Published 2014

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

by Firestein, Ron, Blander, Gil, Michan, Shaday, Oberdoerffer, Philipp, Ogino, Shuji, Campbell, Jennifer, Bhimavarapu, Anupama, Luikenhuis, Sandra, de Cabo, Rafael, Fuchs, Charles, Hahn, William C., Guarente, Leonard P., Sinclair, David A.
Published 2008

Sirtuin1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy

by Michan, Shaday, Juan, Aimee M., Hurst, Christian G., Cui, Zhenghao, Evans, Lucy P., Hatton, Colman J., Pei, Dorothy T., Ju, Meihua, Sinclair, David A., Smith, Lois E. H., Chen, Jing
Published 2014

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

by Van Meter, Michael, Simon, Matthew, Tombline, Gregory, May, Alfred, Morello, Timothy D., Hubbard, Basil P., Bredbenner, Katie, Park, Rosa, Sinclair, David A., Bohr, Vilhelm A., Gorbunova, Vera, Seluanov, Andrei
Published 2016

Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency

by Cagnone, Gael L. M., Tsai, Te-Sha, Makanji, Yogeshwar, Matthews, Pamela, Gould, Jodee, Bonkowski, Michael S., Elgass, Kirstin D., Wong, Ashley S. A., Wu, Lindsay E., McKenzie, Matthew, Sinclair, David A., John, Justin C. St.
Published 2016

Metformin improves healthspan and lifespan in mice

by Martin-Montalvo, Alejandro, Mercken, Evi M., Mitchell, Sarah J., Palacios, Hector H., Mote, Patricia L., Scheibye-Knudsen, Morten, Gomes, Ana P., Ward, Theresa M., Minor, Robin K., Blouin, Marie-José, Schwab, Matthias, Pollak, Michael, Zhang, Yongqing, Yu, Yinbing, Becker, Kevin G., Bohr, Vilhelm A., Ingram, Donald K., Sinclair, David A., Wolf, Norman S., Spindler, Stephen R., Bernier, Michel, de Cabo, Rafael
Published 2013

SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition*

by Abdesselem, Houari, Madani, Aisha, Hani, Ahmad, Al-Noubi, Muna, Goswami, Neha, Ben Hamidane, Hisham, Billing, Anja M., Pasquier, Jennifer, Bonkowski, Michael S., Halabi, Najeeb, Dalloul, Rajaa, Sheriff, Mohamed Z., Mesaeli, Nasrin, ElRayess, Mohamed, Sinclair, David A., Graumann, Johannes, Mazloum, Nayef A.
Published 2016

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

by Mercken, Evi M, Mitchell, Sarah J, Martin-Montalvo, Alejandro, Minor, Robin K, Almeida, Maria, Gomes, Ana P, Scheibye-Knudsen, Morten, Palacios, Hector H, Licata, Jordan J, Zhang, Yongqing, Becker, Kevin G, Khraiwesh, Husam, González-Reyes, José A, Villalba, José M, Baur, Joseph A, Elliott, Peter, Westphal, Christoph, Vlasuk, George P, Ellis, James L, Sinclair, David A, Bernier, Michel, de Cabo, Rafael
Published 2014

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

by Rumpf, Tobias, Schiedel, Matthias, Karaman, Berin, Roessler, Claudia, North, Brian J., Lehotzky, Attila, Oláh, Judit, Ladwein, Kathrin I., Schmidtkunz, Karin, Gajer, Markus, Pannek, Martin, Steegborn, Clemens, Sinclair, David A., Gerhardt, Stefan, Ovádi, Judit, Schutkowski, Mike, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred
Published 2015

The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

by Miranda, Melroy X., van Tits, Lambertus J., Lohmann, Christine, Arsiwala, Tasneem, Winnik, Stephan, Tailleux, Anne, Stein, Sokrates, Gomes, Ana P., Suri, Vipin, Ellis, James L., Lutz, Thomas A., Hottiger, Michael O., Sinclair, David A., Auwerx, Johan, Schoonjans, Kristina, Staels, Bart, Lüscher, Thomas F., Matter, Christian M.
Published 2015