Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Sirtuins are a highly conserved class of NAD+-dependent lysine deacylases. The human isotype Sirt2 has been implicated in the pathogenesis of cancer, inflammation and neurodegeneration, which makes the modulation of Sirt2 activity a promising strategy for pharmaceutical intervention. A rational basi...

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Bibliographic Details
Main Authors: Rumpf, Tobias, Schiedel, Matthias, Karaman, Berin, Roessler, Claudia, North, Brian J., Lehotzky, Attila, Oláh, Judit, Ladwein, Kathrin I., Schmidtkunz, Karin, Gajer, Markus, Pannek, Martin, Steegborn, Clemens, Sinclair, David A., Gerhardt, Stefan, Ovádi, Judit, Schutkowski, Mike, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339887/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339887/

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