SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model

by Wiewel, Maryse A, van der Meer, Anne Jan, Haddad, Jonathan, Jacobson, Eric W, Vlasuk, George P, van der Poll, Tom
Published 2013

Sirtuin 1 activator SRT2104 protects Huntington's disease mice

by Jiang, Mali, Zheng, Jennifer, Peng, Qi, Hou, Zhipeng, Zhang, Jiangyang, Mori, Susumu, Ellis, James L, Vlasuk, George P, Fries, Harvey, Suri, Vipin, Duan, Wenzhen
Published 2014

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

by Yang, Hongying, Zhang, Wei, Pan, Heng, Feldser, Heidi G., Lainez, Elden, Miller, Christine, Leung, Stewart, Zhong, Zhong, Zhao, Huizhen, Sweitzer, Sharon, Considine, Thomas, Riera, Thomas, Suri, Vipin, White, Brian, Ellis, James L., Vlasuk, George P., Loh, Christine
Published 2012

A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers

by Libri, Vincenzo, Brown, Andrew P., Gambarota, Giulio, Haddad, Jonathan, Shields, Gregory S., Dawes, Helen, Pinato, David J., Hoffman, Ethan, Elliot, Peter J., Vlasuk, George P., Jacobson, Eric, Wilkins, Martin R., Matthews, Paul M.
Published 2012

Cardiovascular Effects of a Novel SIRT1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers

by Venkatasubramanian, Sowmya, Noh, Radzi Mohd, Daga, Shruti, Langrish, Jeremy P., Joshi, Nikhil V., Mills, Nicholas L., Hoffmann, Ethan, Jacobson, Eric W., Vlasuk, George P., Waterhouse, Brian R., Lang, Ninian N., Newby, David E.
Published 2013

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis

by Krueger, James G., Suárez-Fariñas, Mayte, Cueto, Inna, Khacherian, Artemis, Matheson, Robert, Parish, Lawrence C., Leonardi, Craig, Shortino, Denise, Gupta, Akanksha, Haddad, Jonathan, Vlasuk, George P., Jacobson, Eric W.
Published 2015

APJ ACTS AS A DUAL RECEPTOR IN CARDIAC HYPERTROPHY

by Scimia, Maria Cecilia, Hurtado, Cecilia, Ray, Saugata, Metzler, Scott, Wei, Ke, Wang, Jianming, Woods, Chris E., Purcell, Nicole H., Catalucci, Daniele, Akasaka, Takashi, Bueno, Orlando F., Vlasuk, George P., Kaliman, Perla, Bodmer, Rolf, Smith, Layton H., Ashley, Euan, Mercola, Mark, Brown, Joan Heller, Ruiz-Lozano, Pilar
Published 2012

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

by Mercken, Evi M, Mitchell, Sarah J, Martin-Montalvo, Alejandro, Minor, Robin K, Almeida, Maria, Gomes, Ana P, Scheibye-Knudsen, Morten, Palacios, Hector H, Licata, Jordan J, Zhang, Yongqing, Becker, Kevin G, Khraiwesh, Husam, González-Reyes, José A, Villalba, José M, Baur, Joseph A, Elliott, Peter, Westphal, Christoph, Vlasuk, George P, Ellis, James L, Sinclair, David A, Bernier, Michel, de Cabo, Rafael
Published 2014

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

by Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.
Published 2015

SRT1720 improves survival and healthspan of obese mice

by Minor, Robin K., Baur, Joseph A., Gomes, Ana P., Ward, Theresa M., Csiszar, Anna, Mercken, Evi M., Abdelmohsen, Kotb, Shin, Yu-Kyong, Canto, Carles, Scheibye-Knudsen, Morten, Krawczyk, Melissa, Irusta, Pablo M., Martín-Montalvo, Alejandro, Hubbard, Basil P., Zhang, Yongqing, Lehrmann, Elin, White, Alexa A., Price, Nathan L., Swindell, William R., Pearson, Kevin J., Becker, Kevin G., Bohr, Vilhelm A., Gorospe, Myriam, Egan, Josephine M., Talan, Mark I., Auwerx, Johan, Westphal, Christoph H., Ellis, James L., Ungvari, Zoltan, Vlasuk, George P., Elliott, Peter J., Sinclair, David A., de Cabo, Rafael
Published 2011

CORRIGENDUM: SRT1720 improves survival and healthspan of obese mice

by Minor, Robin K., Baur, Joseph A., Gomes, Ana P., Ward, Theresa M., Csiszar, Anna, Mercken, Evi M., Abdelmohsen, Kotb, Shin, Yu-Kyong, Canto, Carles, Scheibye-Knudsen, Morten, Krawczyk, Melissa, Irusta, Pablo M., Martín-Montalvo, Alejandro, Hubbard, Basil P., Zhang, Yongqing, Lehrmann, Elin, White, Alexa A., Price, Nathan L., Swindell, William R., Pearson, Kevin J., Becker, Kevin G., Bohr, Vilhelm A., Gorospe, Myriam, Egan, Josephine M., Talan, Mark I., Auwerx, Johan, Westphal, Christoph H., Ellis, James L., Ungvari, Zoltan, Vlasuk, George P., Elliott, Peter J., Sinclair, David A., de Cabo, Rafael
Published 2013