Sirtuin 1 activator SRT2104 protects Huntington's disease mice

by Jiang, Mali, Zheng, Jennifer, Peng, Qi, Hou, Zhipeng, Zhang, Jiangyang, Mori, Susumu, Ellis, James L, Vlasuk, George P, Fries, Harvey, Suri, Vipin, Duan, Wenzhen
Published 2014

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

by Yang, Hongying, Zhang, Wei, Pan, Heng, Feldser, Heidi G., Lainez, Elden, Miller, Christine, Leung, Stewart, Zhong, Zhong, Zhao, Huizhen, Sweitzer, Sharon, Considine, Thomas, Riera, Thomas, Suri, Vipin, White, Brian, Ellis, James L., Vlasuk, George P., Loh, Christine
Published 2012

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

by Mercken, Evi M, Mitchell, Sarah J, Martin-Montalvo, Alejandro, Minor, Robin K, Almeida, Maria, Gomes, Ana P, Scheibye-Knudsen, Morten, Palacios, Hector H, Licata, Jordan J, Zhang, Yongqing, Becker, Kevin G, Khraiwesh, Husam, González-Reyes, José A, Villalba, José M, Baur, Joseph A, Elliott, Peter, Westphal, Christoph, Vlasuk, George P, Ellis, James L, Sinclair, David A, Bernier, Michel, de Cabo, Rafael
Published 2014

The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

by Miranda, Melroy X., van Tits, Lambertus J., Lohmann, Christine, Arsiwala, Tasneem, Winnik, Stephan, Tailleux, Anne, Stein, Sokrates, Gomes, Ana P., Suri, Vipin, Ellis, James L., Lutz, Thomas A., Hottiger, Michael O., Sinclair, David A., Auwerx, Johan, Schoonjans, Kristina, Staels, Bart, Lüscher, Thomas F., Matter, Christian M.
Published 2015

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

by Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.
Published 2015

SRT1720 improves survival and healthspan of obese mice

by Minor, Robin K., Baur, Joseph A., Gomes, Ana P., Ward, Theresa M., Csiszar, Anna, Mercken, Evi M., Abdelmohsen, Kotb, Shin, Yu-Kyong, Canto, Carles, Scheibye-Knudsen, Morten, Krawczyk, Melissa, Irusta, Pablo M., Martín-Montalvo, Alejandro, Hubbard, Basil P., Zhang, Yongqing, Lehrmann, Elin, White, Alexa A., Price, Nathan L., Swindell, William R., Pearson, Kevin J., Becker, Kevin G., Bohr, Vilhelm A., Gorospe, Myriam, Egan, Josephine M., Talan, Mark I., Auwerx, Johan, Westphal, Christoph H., Ellis, James L., Ungvari, Zoltan, Vlasuk, George P., Elliott, Peter J., Sinclair, David A., de Cabo, Rafael
Published 2011

CORRIGENDUM: SRT1720 improves survival and healthspan of obese mice

by Minor, Robin K., Baur, Joseph A., Gomes, Ana P., Ward, Theresa M., Csiszar, Anna, Mercken, Evi M., Abdelmohsen, Kotb, Shin, Yu-Kyong, Canto, Carles, Scheibye-Knudsen, Morten, Krawczyk, Melissa, Irusta, Pablo M., Martín-Montalvo, Alejandro, Hubbard, Basil P., Zhang, Yongqing, Lehrmann, Elin, White, Alexa A., Price, Nathan L., Swindell, William R., Pearson, Kevin J., Becker, Kevin G., Bohr, Vilhelm A., Gorospe, Myriam, Egan, Josephine M., Talan, Mark I., Auwerx, Johan, Westphal, Christoph H., Ellis, James L., Ungvari, Zoltan, Vlasuk, George P., Elliott, Peter J., Sinclair, David A., de Cabo, Rafael
Published 2013