O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway
Tumors utilize aerobic glycolysis to support growth and invasion. However, the molecular mechanisms that link metabolism with invasion are not well understood. The nutrient sensor O-linked-β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) modifies intracellular proteins with N-acetylglucosamine. Ca...
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2016
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192006/ |