Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair

by Reynolds, John J., Walker, Alexandra K., Gilmore, Edward C., Walsh, Christopher A., Caldecott, Keith W.
Published 2012

Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair?

by Cui, Xiuji, McAllister, Rebecca, Boregowda, Rajeev, Sohn, Ji A., Ledesma, Felipe Cortes, Caldecott, Keith W., Seeger, Christoph, Hu, Jianming
Published 2015

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function

by Breslin, Claire, Hornyak, Peter, Ridley, Andrew, Rulten, Stuart L., Hanzlikova, Hana, Oliver, Antony W., Caldecott, Keith W.
Published 2015

Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains

by Cherry, Amy L., Nott, Timothy J., Kelly, Geoffrey, Rulten, Stuart L., Caldecott, Keith W., Smerdon, Stephen J.
Published 2015

Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections

by Maciejewski, Sonia, Nguyen, Joseph H. C., Gómez-Herreros, Fernando, Cortés-Ledesma, Felipe, Caldecott, Keith W., Semler, Bert L.
Published 2015

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage

by Rulten, Stuart L., Rotheray, Amy, Green, Ryan L., Grundy, Gabrielle J., Moore, Duncan A. Q., Gómez-Herreros, Fernando, Hafezparast, Majid, Caldecott, Keith W
Published 2014

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

by Zeng, Zhihong, Sharma, Abhishek, Ju, Limei, Murai, Junko, Umans, Lieve, Vermeire, Liesbeth, Pommier, Yves, Takeda, Shunichi, Huylebroeck, Danny, Caldecott, Keith W., El-Khamisy, Sherif F.
Published 2012

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

by Gómez-Herreros, Fernando, Romero-Granados, Rocío, Zeng, Zhihong, Álvarez-Quilón, Alejandro, Quintero, Cristina, Ju, Limei, Umans, Lieve, Vermeire, Liesbeth, Huylebroeck, Danny, Caldecott, Keith W., Cortés-Ledesma, Felipe
Published 2013

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

by Grundy, Gabrielle J., Rulten, Stuart L., Arribas-Bosacoma, Raquel, Davidson, Kathryn, Kozik, Zuzanna, Oliver, Antony W., Pearl, Laurence H., Caldecott, Keith W.
Published 2016

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

by Grundy, Gabrielle J., Polo, Luis M., Zeng, Zhihong, Rulten, Stuart L., Hoch, Nicolas C., Paomephan, Pathompong, Xu, Yingqi, Sweet, Steve M., Thorne, Alan W., Oliver, Antony W., Matthews, Steve J., Pearl, Laurence H., Caldecott, Keith W.
Published 2016

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2

by Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E., Bartlett, Edward J., Brissett, Nigel C., Raoof, Ali, Watson, Mandy, Jordan, Allan M., Ogilvie, Donald J., Ward, Simon E., Atack, John R., Pearl, Laurence H., Caldecott, Keith W., Oliver, Antony W.
Published 2016