Sequence selectivity of the cleavage sites induced by topoisomerase I inhibitors: a molecular dynamics study

by Siu, Fung-Ming, Pommier, Yves
Published 2013

Optimization of the Lactam Side Chain of 7-Azaindenoisoquinoline Topoisomerase I Inhibitors and Mechanism of Action Studies in Cancer Cells

by Kiselev, Evgeny, Sooryakumar, Dhriti, Agama, Keli, Cushman, Mark, Pommier, Yves
Published 2014

Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC

by Zoppoli, Gabriele, Douarre, Céline, Dalla Rosa, Ilaria, Liu, Hongfang, Reinhold, William, Pommier, Yves
Published 2011

Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells

by Rehman, Abdur, Chahal, Manpreet S, Tang, Xiaoting, Bruce, James E, Pommier, Yves, Daoud, Sayed S
Published 2005

Gene Expression Profiles of the NCI-60 Human Tumor Cell Lines Define Molecular Interaction Networks Governing Cell Migration Processes

by Kohn, Kurt W., Zeeberg, Barry R., Reinhold, William C., Sunshine, Margot, Luna, Augustin, Pommier, Yves
Published 2012

Mass Homozygotes Accumulation in the NCI-60 Cancer Cell Lines As Compared to HapMap Trios, and Relation to Fragile Site Location

by Ruan, Xiaoyang, Kocher, Jean-Pierre A., Pommier, Yves, Liu, Hongfang, Reinhold, William C.
Published 2012

Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

by Zhang, Yong-Wei, Regairaz, Marie, Seiler, Jennifer A., Agama, Keli K., Doroshow, James H., Pommier, Yves
Published 2011

Depicting combinatorial complexity with the molecular interaction map notation

by Kohn, Kurt W, Aladjem, Mirit I, Kim, Sohyoung, Weinstein, John N, Pommier, Yves
Published 2006

Identification of a Predominant Co-Regulation among Kinetochore Genes, Prospective Regulatory Elements, and Association with Genomic Instability

by Reinhold, William C., Erliandri, Indri, Liu, Hongfang, Zoppoli, Gabriele, Pommier, Yves, Larionov, Vladimir
Published 2011

Exploring DNA Topoisomerase I Ligand Space in Search of Novel Anticancer Agents

by Drwal, Malgorzata N., Agama, Keli, Wakelin, Laurence P. G., Pommier, Yves, Griffith, Renate
Published 2011

G4 motifs correlate with promoter-proximal transcriptional pausing in human genes

by Eddy, Johanna, Vallur, Aarthy C., Varma, Sudir, Liu, Hongfang, Reinhold, William C., Pommier, Yves, Maizels, Nancy
Published 2011

Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I

by Xu, Lixin, Yang, Lihong, Hashimoto, Keiko, Anderson, Melvin, Kohlhagen, Glenda, Pommier, Yves, D'Arpa, Peter
Published 2002

Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target

by Zhang, Fang, Rothermund, Kristi, Gangadharan, Sajithlal B., Pommier, Yves, Prochownik, Edward V., Lazo, John S.
Published 2012

Solvent Dependency of the UV-Vis Spectrum of Indenoisoquinolines: Role of Keto-Oxygens as Polarity Interaction Probes

by Coletta, Andrea, Castelli, Silvia, Chillemi, Giovanni, Sanna, Nico, Cushman, Mark, Pommier, Yves, Desideri, Alessandro
Published 2013

Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction

by Mancini, Giordano, D’Annessa, Ilda, Coletta, Andrea, Chillemi, Giovanni, Pommier, Yves, Cushman, Mark, Desideri, Alessandro
Published 2012

Structural basis for recognition of 5′-phosphotyrosine adducts by TDP2

by Shi, Ke, Kurahashi, Kayo, Gao, Rui, Tsutakawa, Susan E, Tainer, John A, Pommier, Yves, Aihara, Hideki
Published 2012

Synthesis and Biological Evaluation of New Carbohydrate-Substituted Indenoisoquinoline Topoisomerase I Inhibitors and Improved Syntheses of the Experimental Anticancer Agents Indot...

by Beck, Daniel E., Agama, Keli, Marchand, Christophe, Chergui, Adel, Pommier, Yves, Cushman, Mark
Published 2014

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria

by Zhang, Hongliang, Zhang, Yong-Wei, Yasukawa, Takehiro, Dalla Rosa, Ilaria, Khiati, Salim, Pommier, Yves
Published 2014

Gene Expression Correlations in Human Cancer Cell Lines Define Molecular Interaction Networks for Epithelial Phenotype

by Kohn, Kurt W., Zeeberg, Barry M., Reinhold, William C., Pommier, Yves
Published 2014

High Resolution Copy Number Variation Data in the NCI-60 Cancer Cell Lines from Whole Genome Microarrays Accessible through CellMiner

by Varma, Sudhir, Pommier, Yves, Sunshine, Margot, Weinstein, John N., Reinhold, William C.
Published 2014