TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

Anticancer topoisomerase “poisons” exploit the break-and-rejoining mechanism of topoisomerase II (TOP2) to generate TOP2-linked DNA double-strand breaks (DSBs). This characteristic underlies the clinical efficacy of TOP2 poisons, but is also implicated in chromosomal translocations and genome instab...

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Bibliographic Details
Main Authors: Gómez-Herreros, Fernando, Romero-Granados, Rocío, Zeng, Zhihong, Álvarez-Quilón, Alejandro, Quintero, Cristina, Ju, Limei, Umans, Lieve, Vermeire, Liesbeth, Huylebroeck, Danny, Caldecott, Keith W., Cortés-Ledesma, Felipe
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592926/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592926/

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