Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains

Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains

•Aprataxin and APLF FHA domains show distinct specificities for XRCC4 and XRCC1.•Specificity is modulated by multi-site phosphorylation.•The crystal structure of APLF FHA and triphosphorylated XRCC4 peptide reveals a conserved mode of core pSpT motif binding.•Overall phospho-dependent binding versat...

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Bibliographic Details
Main Authors: Cherry, Amy L., Nott, Timothy J., Kelly, Geoffrey, Rulten, Stuart L., Caldecott, Keith W., Smerdon, Stephen J.
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655838/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655838/

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