Determination of antiprotozoal drug mechanisms by metabolomics approaches

by CREEK, DARREN J., BARRETT, MICHAEL P.
Published 2014

mzMatch–ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data

by Chokkathukalam, Achuthanunni, Jankevics, Andris, Creek, Darren J., Achcar, Fiona, Barrett, Michael P., Breitling, Rainer
Published 2013

Stable Isotope-Assisted Metabolomics for Network-Wide Metabolic Pathway Elucidation

by Creek, Darren J., Chokkathukalam, Achuthanunni, Jankevics, Andris, Burgess, Karl E. V., Breitling, Rainer, Barrett, Michael P.
Published 2012

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

by Trochine, Andrea, Creek, Darren J., Faral-Tello, Paula, Barrett, Michael P., Robello, Carlos
Published 2014

Strategies for Extending Metabolomics Studies with Stable Isotope Labelling and Fluxomics

by Srivastava, Anubhav, Kowalski, Greg M., Callahan, Damien L., Meikle, Peter J., Creek, Darren J.
Published 2016

Optimized Method for Untargeted Metabolomics Analysis of MDA-MB-231 Breast Cancer Cells

by Peterson, Amanda L., Walker, Adam K., Sloan, Erica K., Creek, Darren J.
Published 2016

Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei

by Vincent, Isabel M., Creek, Darren J., Burgess, Karl, Woods, Debra J., Burchmore, Richard J. S., Barrett, Michael P.
Published 2012

The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii

by Limenitakis, Julien, Oppenheim, Rebecca D, Creek, Darren J, Foth, Bernardo J, Barrett, Michael P, Soldati-Favre, Dominique
Published 2013

Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments

by Srivastava, Anubhav, Philip, Nisha, Hughes, Katie R., Georgiou, Konstantina, MacRae, James I., Barrett, Michael P., Creek, Darren J., McConville, Malcolm J., Waters, Andrew P.
Published 2016

Host Reticulocytes Provide Metabolic Reservoirs That Can Be Exploited by Malaria Parasites

by Srivastava, Anubhav, Creek, Darren J., Evans, Krystal J., De Souza, David, Schofield, Louis, Müller, Sylke, Barrett, Michael P., McConville, Malcolm J., Waters, Andrew P.
Published 2015

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strain...

by Yang, Tuo, Xie, Stanley C., Cao, Pengxing, Giannangelo, Carlo, McCaw, James, Creek, Darren J., Charman, Susan A., Klonis, Nectarios, Tilley, Leann
Published 2016

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

by Mahamad Maifiah, Mohd Hafidz, Cheah, Soon-Ee, Johnson, Matthew D., Han, Mei-Ling, Boyce, John D., Thamlikitkul, Visanu, Forrest, Alan, Kaye, Keith S., Hertzog, Paul, Purcell, Anthony W., Song, Jiangning, Velkov, Tony, Creek, Darren J., Li, Jian
Published 2016

Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria

by Tchaparian, Eskouhie, Sambol, Nancy C., Arinaitwe, Emmanuel, McCormack, Shelley A., Bigira, Victor, Wanzira, Humphrey, Muhindo, Mary, Creek, Darren J., Sukumar, Nitin, Blessborn, Daniel, Tappero, Jordan W., Kakuru, Abel, Bergqvist, Yngve, Aweeka, Francesca T., Parikh, Sunil
Published 2016

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii

by Tran, Thien B., Cheah, Soon-Ee, Yu, Heidi H., Bergen, Phillip J., Nation, Roger L., Creek, Darren J., Purcell, Anthony, Forrest, Alan, Doi, Yohei, Song, Jiangning, Velkov, Tony, Li, Jian
Published 2015

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

by Mahamad Maifiah, Mohd Hafidz, Cheah, Soon-Ee, Johnson, Matthew D., Han, Mei-Ling, Boyce, John D., Thamlikitkul, Visanu, Forrest, Alan, Kaye, Keith S., Hertzog, Paul, Purcell, Anthony W., Song, Jiangning, Velkov, Tony, Creek, Darren J., Li, Jian
Published 2016

BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei

by Oppenheim, Rebecca D., Creek, Darren J., Macrae, James I., Modrzynska, Katarzyna K., Pino, Paco, Limenitakis, Julien, Polonais, Valerie, Seeber, Frank, Barrett, Michael P., Billker, Oliver, McConville, Malcolm J., Soldati-Favre, Dominique
Published 2014

Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana

by Mwenechanya, Roy, Kovarova, Julie, Dickens, Nicholas J., Mudaliar, Manikhandan, Herzyk, Pawel, Vicent, Isabel M., Weidt, Stefan K., Burgess, Karl E., Burchmore, Richard J.S., Pountain, Andrew W., Smith, Terry K., Creek, Darren J., Kim, Dong-Hyun, Lepesheva, Galina I., Barrett, Michael P.
Published 2017

Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose

by Creek, Darren J., Mazet, Muriel, Achcar, Fiona, Anderson, Jana, Kim, Dong-Hyun, Kamour, Ruwida, Morand, Pauline, Millerioux, Yoann, Biran, Marc, Kerkhoven, Eduard J., Chokkathukalam, Achuthanunni, Weidt, Stefan K., Burgess, Karl E. V., Breitling, Rainer, Watson, David G., Bringaud, Frédéric, Barrett, Michael P.
Published 2015

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

by Shameer, Sanu, Logan-Klumpler, Flora J., Vinson, Florence, Cottret, Ludovic, Merlet, Benjamin, Achcar, Fiona, Boshart, Michael, Berriman, Matthew, Breitling, Rainer, Bringaud, Frédéric, Bütikofer, Peter, Cattanach, Amy M., Bannerman-Chukualim, Bridget, Creek, Darren J., Crouch, Kathryn, de Koning, Harry P., Denise, Hubert, Ebikeme, Charles, Fairlamb, Alan H., Ferguson, Michael A. J., Ginger, Michael L., Hertz-Fowler, Christiane, Kerkhoven, Eduard J., Mäser, Pascal, Michels, Paul A. M., Nayak, Archana, Nes, David W., Nolan, Derek P., Olsen, Christian, Silva-Franco, Fatima, Smith, Terry K., Taylor, Martin C., Tielens, Aloysius G. M., Urbaniak, Michael D., van Hellemond, Jaap J., Vincent, Isabel M., Wilkinson, Shane R., Wyllie, Susan, Opperdoes, Fred R., Barrett, Michael P., Jourdan, Fabien
Published 2015