Methylglyoxal metabolism in trypanosomes and leishmania

by Wyllie, Susan, Fairlamb, Alan H.
Published 2011

The N-myristoylome of Trypanosoma cruzi

by Roberts, Adam J., Fairlamb, Alan H.
Published 2016

Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major*

by Ong, Han B., Sienkiewicz, Natasha, Wyllie, Susan, Fairlamb, Alan H.
Published 2011

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

by Jones, Deuan C, Alphey, Magnus S, Wyllie, Susan, Fairlamb, Alan H
Published 2012

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

by Roberts, Adam J., Torrie, Leah S., Wyllie, Susan, Fairlamb, Alan H.
Published 2014

Target Validation: Linking Target and Chemical Properties to Desired Product Profile

by Wyatt, Paul G, Gilbert, Ian H, Read, Kevin D, Fairlamb, Alan H
Published 2011

A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes

by De Rycker, Manu, O'Neill, Sandra, Joshi, Dhananjay, Campbell, Lorna, Gray, David W., Fairlamb, Alan H.
Published 2012

Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

by Ong, Han B, Sienkiewicz, Natasha, Wyllie, Susan, Patterson, Stephen, Fairlamb, Alan H
Published 2013

Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog*♦

by Nguyen, Suong, Jones, Deuan C., Wyllie, Susan, Fairlamb, Alan H., Phillips, Margaret A.
Published 2013

The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei*

by Dewar, Simon, Sienkiewicz, Natasha, Ong, Han B., Wall, Richard J., Horn, David, Fairlamb, Alan H.
Published 2016

Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase

by Gibson, Marc W., Dewar, Simon, Ong, Han B., Sienkiewicz, Natasha, Fairlamb, Alan H.
Published 2016

Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei

by Ong, Han B, Lee, Wai S, Patterson, Stephen, Wyllie, Susan, Fairlamb, Alan H
Published 2015

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei

by Wyllie, Susan, Foth, Bernardo J., Kelner, Anna, Sokolova, Antoaneta Y., Berriman, Matthew, Fairlamb, Alan H.
Published 2016

Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the Indian Subcontinent?

by Perry, Meghan R., Wyllie, Susan, Prajapati, Vijay Kumar, Feldmann, Joerg, Sundar, Shyam, Boelaert, Marleen, Fairlamb, Alan H.
Published 2011

Norspermidine Is Not a Self-Produced Trigger for Biofilm Disassembly

by Hobley, Laura, Kim, Sok Ho, Maezato, Yukari, Wyllie, Susan, Fairlamb, Alan H., Stanley-Wall, Nicola R., Michael, Anthony J.
Published 2014

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

by Wyllie, Susan, Roberts, Adam J., Norval, Suzanne, Patterson, Stephen, Foth, Bernardo J., Berriman, Matthew, Read, Kevin D., Fairlamb, Alan H.
Published 2016

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

by Jones, Deuan C., Foth, Bernardo J., Urbaniak, Michael D., Patterson, Stephen, Ong, Han B., Berriman, Matthew, Fairlamb, Alan H.
Published 2015

Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate

by Dawson, Alice, Gibellini, Federica, Sienkiewicz, Natasha, Tulloch, Lindsay B, Fyfe, Paul K, McLuskey, Karen, Fairlamb, Alan H, Hunter, William N
Published 2006

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallo...

by Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.
Published 2011

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

by Spinks, Daniel, Torrie, Leah S, Thompson, Stephen, Harrison, Justin R, Frearson, Julie A, Read, Kevin D, Fairlamb, Alan H, Wyatt, Paul G, Gilbert, Ian H
Published 2012