Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells

Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells

In vitro differentiation of human pluripotent stem cells (hPSCs) recapitulates early aspects of human embryogenesis, but the underlying processes are poorly understood and controlled. Here we show that modulating the bulk cell density (BCD: cell number per culture volume) deterministically alters an...

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Bibliographic Details
Main Authors: Kempf, Henning, Olmer, Ruth, Haase, Alexandra, Franke, Annika, Bolesani, Emiliano, Schwanke, Kristin, Robles-Diaz, Diana, Coffee, Michelle, Göhring, Gudrun, Dräger, Gerald, Pötz, Oliver, Joos, Thomas, Martinez-Hackert, Erik, Haverich, Axel, Buettner, Falk F. R., Martin, Ulrich, Zweigerdt, Robert
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155150/

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