TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-Dependent Cytokinesis Failure

TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-Dependent Cytokinesis Failure

In all mammals, the adult liver shows binucleated as well as mononucleated polyploid hepatocytes. The hepatic polyploidization starts after birth with an extensive hepatocyte binucleation and generates hepatocytes of several ploidy classes. While the functional significance of hepatocyte polyploidy...

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Bibliographic Details
Main Authors: De Santis Puzzonia, Marco, Cozzolino, Angela Maria, Grassi, Germana, Bisceglia, Francesca, Strippoli, Raffaele, Guarguaglini, Giulia, Citarella, Franca, Sacchetti, Benedetto, Tripodi, Marco, Marchetti, Alessandra, Amicone, Laura
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125678/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125678/

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