NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner

NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner

The GDNF (Glial cell line-derived neurotrophic factor)/Ret/Akt signaling pathway is essential to the development of ENS (enteric nervous system) as well as kidney. We previously showed that the HECT-type E3 ligase NEDL2 (Nedd4-like ligase 2) is required for the ENS development by activating GDNF/Ret...

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Bibliographic Details
Main Authors:	Qiu, Xiao, Wei, Rongfei, Li, Yang, Zhu, Qiong, Xiong, Cong, Chen, Yuhan, Zhang, Yuan, Lu, Kefeng, He, Fuchu, Zhang, Lingqiang
Format:	Online
Language:	English
Published:	Impact Journals LLC 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058769/

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