NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner
The GDNF (Glial cell line-derived neurotrophic factor)/Ret/Akt signaling pathway is essential to the development of ENS (enteric nervous system) as well as kidney. We previously showed that the HECT-type E3 ligase NEDL2 (Nedd4-like ligase 2) is required for the ENS development by activating GDNF/Ret...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2016
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058769/ |