NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801
N-methyl-d-aspartate (NMDA) receptors are expressed throughout the kidney, and the abundance of these receptors and some of their endogenous agonists are increased in diabetes. Moreover, sustained activation of podocyte NMDA receptors induces Ca2+ influx, oxidative stress, loss of slit diaphragm pro...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
American Diabetes Association
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033270/ |