NMDA receptor structures reveal subunit arrangement and pore architecture

N-methyl-d-aspartate (NMDA) receptors are Hebbian-like coincidence detectors, requiring binding of glycine and glutamate in combination with the relief of voltage-dependent magnesium block to open an ion conductive pore across the membrane bilayer. Despite the importance of the NMDA receptor in the...

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Bibliographic Details
Main Authors: Lee, Chia-Hsueh, Lü, Wei, Michel, Jennifer Carlisle, Goehring, April, Du, Juan, Song, Xianqiang, Gouaux, Eric
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263351/