Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure
MK-801 is a use-dependent NMDA receptor open channel blocker with a very slow off-rate. These properties can be exploited to ‘pre-block’ a population of NMDARs, such as synaptic ones, enabling the selective activation of a different population, such as extrasynaptic NMDARs. However, the usefulness o...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Pergamon Press
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778432/ |