Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30–50%) than in European/Americans (10–20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japa...

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Main Authors: Shiraishi, Kouya, Okada, Yukinori, Takahashi, Atsushi, Kamatani, Yoichiro, Momozawa, Yukihide, Ashikawa, Kyota, Kunitoh, Hideo, Matsumoto, Shingo, Takano, Atsushi, Shimizu, Kimihiro, Goto, Akiteru, Tsuta, Koji, Watanabe, Shun-ichi, Ohe, Yuichiro, Watanabe, Yukio, Goto, Yasushi, Nokihara, Hiroshi, Furuta, Koh, Yoshida, Akihiko, Goto, Koichi, Hishida, Tomoyuki, Tsuboi, Masahiro, Tsuchihara, Katsuya, Miyagi, Yohei, Nakayama, Haruhiko, Yokose, Tomoyuki, Tanaka, Kazumi, Nagashima, Toshiteru, Ohtaki, Yoichi, Maeda, Daichi, Imai, Kazuhiro, Minamiya, Yoshihiro, Sakamoto, Hiromi, Saito, Akira, Shimada, Yoko, Sunami, Kuniko, Saito, Motonobu, Inazawa, Johji, Nakamura, Yusuke, Yoshida, Teruhiko, Yokota, Jun, Matsuda, Fumihiko, Matsuo, Keitaro, Daigo, Yataro, Kubo, Michiaki, Kohno, Takashi
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980483/

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