Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma
Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30–50%) than in European/Americans (10–20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japa...
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| Format: | Online |
| Language: | English |
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Nature Publishing Group
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980483/ |
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pubmed-49804832016-08-12 Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma Shiraishi, Kouya Okada, Yukinori Takahashi, Atsushi Kamatani, Yoichiro Momozawa, Yukihide Ashikawa, Kyota Kunitoh, Hideo Matsumoto, Shingo Takano, Atsushi Shimizu, Kimihiro Goto, Akiteru Tsuta, Koji Watanabe, Shun-ichi Ohe, Yuichiro Watanabe, Yukio Goto, Yasushi Nokihara, Hiroshi Furuta, Koh Yoshida, Akihiko Goto, Koichi Hishida, Tomoyuki Tsuboi, Masahiro Tsuchihara, Katsuya Miyagi, Yohei Nakayama, Haruhiko Yokose, Tomoyuki Tanaka, Kazumi Nagashima, Toshiteru Ohtaki, Yoichi Maeda, Daichi Imai, Kazuhiro Minamiya, Yoshihiro Sakamoto, Hiromi Saito, Akira Shimada, Yoko Sunami, Kuniko Saito, Motonobu Inazawa, Johji Nakamura, Yusuke Yoshida, Teruhiko Yokota, Jun Matsuda, Fumihiko Matsuo, Keitaro Daigo, Yataro Kubo, Michiaki Kohno, Takashi Article Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30–50%) than in European/Americans (10–20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3 (BTNL2), 3q28 (TP63) and 17q24.2 (BPTF), previously shown to be strongly associated with overall lung adenocarcinoma risk in East Asians, were re-discovered as loci associated with a higher susceptibility to EGFR mutation-positive lung adenocarcinoma. In addition, two additional loci, HLA class II at 6p21.32 (rs2179920; P =5.1 × 10−17, per-allele OR=1.36) and 6p21.1 (FOXP4) (rs2495239; P=3.9 × 10−9, per-allele OR=1.19) were newly identified as loci associated with EGFR mutation-positive lung adenocarcinoma. This study indicates that multiple genetic factors underlie the risk of lung adenocarcinomas with EGFR mutations. Nature Publishing Group 2016-08-09 /pmc/articles/PMC4980483/ /pubmed/27501781 http://dx.doi.org/10.1038/ncomms12451 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Shiraishi, Kouya Okada, Yukinori Takahashi, Atsushi Kamatani, Yoichiro Momozawa, Yukihide Ashikawa, Kyota Kunitoh, Hideo Matsumoto, Shingo Takano, Atsushi Shimizu, Kimihiro Goto, Akiteru Tsuta, Koji Watanabe, Shun-ichi Ohe, Yuichiro Watanabe, Yukio Goto, Yasushi Nokihara, Hiroshi Furuta, Koh Yoshida, Akihiko Goto, Koichi Hishida, Tomoyuki Tsuboi, Masahiro Tsuchihara, Katsuya Miyagi, Yohei Nakayama, Haruhiko Yokose, Tomoyuki Tanaka, Kazumi Nagashima, Toshiteru Ohtaki, Yoichi Maeda, Daichi Imai, Kazuhiro Minamiya, Yoshihiro Sakamoto, Hiromi Saito, Akira Shimada, Yoko Sunami, Kuniko Saito, Motonobu Inazawa, Johji Nakamura, Yusuke Yoshida, Teruhiko Yokota, Jun Matsuda, Fumihiko Matsuo, Keitaro Daigo, Yataro Kubo, Michiaki Kohno, Takashi |
| spellingShingle |
Shiraishi, Kouya Okada, Yukinori Takahashi, Atsushi Kamatani, Yoichiro Momozawa, Yukihide Ashikawa, Kyota Kunitoh, Hideo Matsumoto, Shingo Takano, Atsushi Shimizu, Kimihiro Goto, Akiteru Tsuta, Koji Watanabe, Shun-ichi Ohe, Yuichiro Watanabe, Yukio Goto, Yasushi Nokihara, Hiroshi Furuta, Koh Yoshida, Akihiko Goto, Koichi Hishida, Tomoyuki Tsuboi, Masahiro Tsuchihara, Katsuya Miyagi, Yohei Nakayama, Haruhiko Yokose, Tomoyuki Tanaka, Kazumi Nagashima, Toshiteru Ohtaki, Yoichi Maeda, Daichi Imai, Kazuhiro Minamiya, Yoshihiro Sakamoto, Hiromi Saito, Akira Shimada, Yoko Sunami, Kuniko Saito, Motonobu Inazawa, Johji Nakamura, Yusuke Yoshida, Teruhiko Yokota, Jun Matsuda, Fumihiko Matsuo, Keitaro Daigo, Yataro Kubo, Michiaki Kohno, Takashi Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma |
| author_facet |
Shiraishi, Kouya Okada, Yukinori Takahashi, Atsushi Kamatani, Yoichiro Momozawa, Yukihide Ashikawa, Kyota Kunitoh, Hideo Matsumoto, Shingo Takano, Atsushi Shimizu, Kimihiro Goto, Akiteru Tsuta, Koji Watanabe, Shun-ichi Ohe, Yuichiro Watanabe, Yukio Goto, Yasushi Nokihara, Hiroshi Furuta, Koh Yoshida, Akihiko Goto, Koichi Hishida, Tomoyuki Tsuboi, Masahiro Tsuchihara, Katsuya Miyagi, Yohei Nakayama, Haruhiko Yokose, Tomoyuki Tanaka, Kazumi Nagashima, Toshiteru Ohtaki, Yoichi Maeda, Daichi Imai, Kazuhiro Minamiya, Yoshihiro Sakamoto, Hiromi Saito, Akira Shimada, Yoko Sunami, Kuniko Saito, Motonobu Inazawa, Johji Nakamura, Yusuke Yoshida, Teruhiko Yokota, Jun Matsuda, Fumihiko Matsuo, Keitaro Daigo, Yataro Kubo, Michiaki Kohno, Takashi |
| author_sort |
Shiraishi, Kouya |
| title |
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma |
| title_short |
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma |
| title_full |
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma |
| title_fullStr |
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma |
| title_full_unstemmed |
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma |
| title_sort |
association of variations in hla class ii and other loci with susceptibility to egfr-mutated lung adenocarcinoma |
| description |
Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30–50%) than in European/Americans (10–20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3 (BTNL2), 3q28 (TP63) and 17q24.2 (BPTF), previously shown to be strongly associated with overall lung adenocarcinoma risk in East Asians, were re-discovered as loci associated with a higher susceptibility to EGFR mutation-positive lung adenocarcinoma. In addition, two additional loci, HLA class II at 6p21.32 (rs2179920; P =5.1 × 10−17, per-allele OR=1.36) and 6p21.1 (FOXP4) (rs2495239; P=3.9 × 10−9, per-allele OR=1.19) were newly identified as loci associated with EGFR mutation-positive lung adenocarcinoma. This study indicates that multiple genetic factors underlie the risk of lung adenocarcinomas with EGFR mutations. |
| publisher |
Nature Publishing Group |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980483/ |
| _version_ |
1613625336706105344 |