MicroRNAs of the miR-290–295 Family Maintain Bivalency in Mouse Embryonic Stem Cells

MicroRNAs of the miR-290–295 Family Maintain Bivalency in Mouse Embryonic Stem Cells

Numerous developmentally regulated genes in mouse embryonic stem cells (ESCs) are marked by both active (H3K4me3)- and polycomb group (PcG)-mediated repressive (H3K27me3) histone modifications. This bivalent state is thought to be important for transcriptional poising, but the mechanisms that regula...

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Bibliographic Details
Main Authors: Graham, Bryony, Marcais, Antoine, Dharmalingam, Gopuraja, Carroll, Thomas, Kanellopoulou, Chryssa, Graumann, Johannes, Nesterova, Tatyana B., Bermange, Anna, Brazauskas, Pijus, Xella, Barbara, Kriaucionis, Skirmantas, Higgs, Douglas R., Brockdorff, Neil, Mann, Matthias, Fisher, Amanda G., Merkenschlager, Matthias
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939759/

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