Design and Characterization of Bivalent BET Inhibitors

Cellular signaling is often propagated by multivalent interactions. Multivalency creates avidity, allowing stable biophysical recognition. Multivalency is an attractive strategy for achieving potent binding to protein targets, as the affinity of bivalent ligands is often greater than the sum of mono...

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Bibliographic Details
Main Authors: Tanaka, Minoru, Roberts, Justin M., Seo, Hyuk-Soo, Souza, Amanda, Paulk, Joshiawa, Scott, Thomas G., DeAngelo, Stephen L., Dhe-Paganon, Sirano, Bradner, James E.
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117811/