IL-1 signaling modulates STAT activation to antagonize retinoic acid signaling and control Th17–iTreg balance

IL-1 signaling modulates STAT activation to antagonize retinoic acid signaling and control Th17–iTreg balance

Interleukin 17 (IL-17)-producing helper (TH17) and inducible regulatory CD4+ T (iTreg) cells emerge from an overlapping developmental program. In the intestines, the vitamin A metabolite retinoic acid (RA) is produced at steady state and acts as an important cofactor to induce iTreg cell development...

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Bibliographic Details
Main Authors: Basu, Rajatava, Whitley, Sarah K., Bhaumik, Suniti, Zindl, Carlene L., Schoeb, Trenton R., Benveniste, Etty N., Pear, Warren S., Hatton, Robin D., Weaver, Casey T.
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790724/

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