JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3

Life and death decisions are made by integrating a variety of apoptotic and survival signals in mammalian cells. Therefore, there is likely to be a common mechanism that integrates multiple signals adjudicating between the alternatives. In this study, we propose that 14-3-3 represents such an integr...

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Bibliographic Details
Main Authors: Sunayama, Jun, Tsuruta, Fuminori, Masuyama, Norihisa, Gotoh, Yukiko
Format: Online
Language:English
Published: The Rockefeller University Press 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171419/