Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling
Several aldo–keto reductase (AKR) enzymes from subfamilies 1B and 1C show retinaldehyde reductase activity, having low Km and kcat values. Only AKR1B10 and 1B12, with all-trans-retinaldehyde, and AKR1C3, with 9-cis-retinaldehyde, display high catalytic efficiency. Major structural determinants for r...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Frontiers Research Foundation
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328219/ |