Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines
Autophagy is an evolutionarily conserved survival pathway in eukaryote and is frequently upregulated in cancer cells after chemotherapy or targeted therapy. Thus induction of autophagy has emerged as a drug resistance mechanism. In this study, we found that crizotinib induced a high level of autopha...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741894/ |