Stereospecific targeting of MTH1 by (S)-crizotinib as anticancer strategy

Stereospecific targeting of MTH1 by (S)-crizotinib as anticancer strategy

Activated Ras GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used to identify experimental small-molecules, such as SCH51344, but their molecular mechanism of action remains generally enigmatic. Here, using...

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Bibliographic Details
Main Authors: Huber, Kilian V. M., Salah, Eidarus, Radic, Branka, Gridling, Manuela, Elkins, Jonathan M., Stukalov, Alexey, Jemth, Ann-Sofie, Gokturk, Camilla, Sanjiv, Kumar, Strömberg, Kia, Pham, Therese, Berglund, Ulrika Warpman, Colinge, Jacques, Bennett, Keiryn L., Loizou, Joanna, Helleday, Thomas, Knapp, Stefan, Superti-Furga, Giulio
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150021/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150021/

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