Autophagy inhibition sensitizes hepatocellular carcinoma to the multikinase inhibitor linifanib

Autophagy is a critical survival pathway for cancer cells under conditions of stress. Thus, induction of autophagy has emerged as a drug resistance mechanism. This study is to determine whether autophagy is activated by a novel multikinase inhibitor linifanib, thereby impairing the sensitivity of he...

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Bibliographic Details
Main Authors: Pan, Hongming, Wang, Zhanggui, Jiang, Liming, Sui, Xinbing, You, Liangkun, Shou, Jiawei, Jing, Zhao, Xie, Jiansheng, Ge, Weiting, Cai, Xiujun, Huang, Wendong, Han, Weidong
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202209/