Basic mechanism for biorientation of mitotic chromosomes is provided by the kinetochore geometry and indiscriminate turnover of kinetochore microtubules
A mathematical model is used to analyze the impact of the indiscriminate kinetochore microtubule turnover and the back-to-back kinetochore geometry on chromosome biorientation during mitosis. The authors show that mammalian kinetochore operates in a near-optimal regime, whereby these two features pr...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710231/ |