Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm

Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm

Intraflagellar transport (IFT) is necessary for the assembly and maintenance of most cilia, with the exception of gametic flagella in some organisms. IFT is required for assembly of mouse sperm flagella, and defects in IFT lead to male infertility. However, mature sperm lack IFT proteins and thus do...

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Main Authors: San Agustin, Jovenal T., Pazour, Gregory J., Witman, George B.
Format: Online
Language:English
Published: The American Society for Cell Biology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666132/
id pubmed-4666132
recordtype oai_dc
spelling pubmed-46661322016-02-16 Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm San Agustin, Jovenal T. Pazour, Gregory J. Witman, George B. Articles Intraflagellar transport (IFT) is necessary for the assembly and maintenance of most cilia, with the exception of gametic flagella in some organisms. IFT is required for assembly of mouse sperm flagella, and defects in IFT lead to male infertility. However, mature sperm lack IFT proteins and thus do not require IFT for maintenance of the axoneme. The American Society for Cell Biology 2015-12-01 /pmc/articles/PMC4666132/ /pubmed/26424803 http://dx.doi.org/10.1091/mbc.E15-08-0578 Text en © 2015 San Agustin et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author San Agustin, Jovenal T.
Pazour, Gregory J.
Witman, George B.
spellingShingle San Agustin, Jovenal T.
Pazour, Gregory J.
Witman, George B.
Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm
author_facet San Agustin, Jovenal T.
Pazour, Gregory J.
Witman, George B.
author_sort San Agustin, Jovenal T.
title Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm
title_short Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm
title_full Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm
title_fullStr Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm
title_full_unstemmed Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm
title_sort intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm
description Intraflagellar transport (IFT) is necessary for the assembly and maintenance of most cilia, with the exception of gametic flagella in some organisms. IFT is required for assembly of mouse sperm flagella, and defects in IFT lead to male infertility. However, mature sperm lack IFT proteins and thus do not require IFT for maintenance of the axoneme.
publisher The American Society for Cell Biology
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666132/
_version_ 1613508384691060736

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