Is RANKL inhibition both anti-resorptive and anabolic in rheumatoid arthritis?
A small peptide, OP3-4, blocks receptor activator of NF-κB from binding to its ligand, receptor activator of NF-κB ligand (RANKL), and was reported recently to inhibit bone resorption, promote bone formation and protect cartilage in a preclinical rheumatoid arthritis model. The latter effects may re...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
BioMed Central
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650503/ |