Is RANKL inhibition both anti-resorptive and anabolic in rheumatoid arthritis?

A small peptide, OP3-4, blocks receptor activator of NF-κB from binding to its ligand, receptor activator of NF-κB ligand (RANKL), and was reported recently to inhibit bone resorption, promote bone formation and protect cartilage in a preclinical rheumatoid arthritis model. The latter effects may re...

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Bibliographic Details
Main Authors: Sims, Natalie A., Romas, Evange
Format: Online
Language:English
Published: BioMed Central 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650503/