Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-κB Activation, and IκBα Degradation

Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-κB Activation, and IκBα Degradation

Osteolytic bone diseases are commonly presented with enhanced osteoclast formation and bone resorption. Sesquiterpene lactone natural compounds have been found to possess anti-inflammatory and immune-modulation effects. Here, we identified three germacrane sesquiterpenes using computer-based virtual...

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Bibliographic Details
Main Authors: Qin, Shengnan, Ang, Estabelle, Dai, Libing, Yang, Xiaohong, Ye, Dongping, Chen, Honghui, Zhou, Lin, Yang, Mingli, Teguh, Dian, Tan, Renxiang, Xu, Jun, Tickner, Jennifer, Pavlos, Nathan J., Xu, Jiake
Format: Online
Language:English
Published: MDPI 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661831/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661831/

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