New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding

New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding

Nodal is a potent embryonic morphogen belonging to the TGF-β superfamily. Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1. Nodal expression is physiologically restricted to embryonic tissues and human embryonic stem cells, is absent in normal...

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Main Authors: Focà, Annalia, Sanguigno, Luca, Focà, Giuseppina, Strizzi, Luigi, Iannitti, Roberta, Palumbo, Rosanna, Hendrix, Mary J. C., Leonardi, Antonio, Ruvo, Menotti, Sandomenico, Annamaria
Format: Online
Language:English
Published: MDPI 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613256/

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