A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO

A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO

Lee et al. show that PGAP6 is a glycosylphosphatidylinositol (GPI)-specific phospholipase A2 expressed on the cell surface. PGAP6 selectively acts on a GPI anchor of CRIPTO, but not its close homologue CRYPTIC, and modulates Nodal signaling during embryonic development.

Bibliographic Details
Main Authors: Lee, Gun-Hee, Fujita, Morihisa, Takaoka, Katsuyoshi, Murakami, Yoshiko, Fujihara, Yoshitaka, Kanzawa, Noriyuki, Murakami, Kei-ichi, Kajikawa, Eriko, Takada, Yoko, Saito, Kazunobu, Ikawa, Masahito, Hamada, Hiroshi, Maeda, Yusuke, Kinoshita, Taroh
Format: Online
Language:English
Published: The Rockefeller University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147002/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147002/

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