IL-4Rα-Dependent Alternative Activation of Macrophages Is Not Decisive for Mycobacterium tuberculosis Pathology and Bacterial Burden in Mice

IL-4Rα-Dependent Alternative Activation of Macrophages Is Not Decisive for Mycobacterium tuberculosis Pathology and Bacterial Burden in Mice

Classical activation of macrophages (caMph or M1) is crucial for host protection against Mycobacterium tuberculosis (Mtb) infection. Evidence suggests that IL-4/IL-13 alternatively activated macrophages (aaMph or M2) are exploited by Mtb to divert microbicidal functions of caMph. To define the funct...

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Bibliographic Details
Main Authors: Guler, Reto, Parihar, Suraj P., Savvi, Suzana, Logan, Erin, Schwegmann, Anita, Roy, Sugata, Nieuwenhuizen, Natalie E., Ozturk, Mumin, Schmeier, Sebastian, Suzuki, Harukazu, Brombacher, Frank
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366092/

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